Metformin reverses PARPi-induced EMT and PD-L1 upregulation in the TNB…
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2020.10.21 17:23
Title : Metformin reverses PARP inhibitors-induced Epithelial-mesenchymal transition and PD-L1 upregulation in the Triple-negative breast cancer
Ye Han, et al. Am J Cancer Res 2019;9(4): 800-815
PARP inhibitors induce the EMT features and the upregulation of PD-L1 in the PARP senstive/resistant cell line.
But, Metformin or Topoisomerase 2 poisons (Doxorubicin, Epirubicin, Daunorubicin) treat about that EMT featured make reversal to MET.
And, Phosphorylation of Akt is important to Reversal of EMT to MET is explained by treat the Akt inhibitor, that reversal of PARPi-induced EMT and PD-L1 upregulation is blocked.
Ye Han, et al. Am J Cancer Res 2019;9(4): 800-815
PARP inhibitors induce the EMT features and the upregulation of PD-L1 in the PARP senstive/resistant cell line.
But, Metformin or Topoisomerase 2 poisons (Doxorubicin, Epirubicin, Daunorubicin) treat about that EMT featured make reversal to MET.
And, Phosphorylation of Akt is important to Reversal of EMT to MET is explained by treat the Akt inhibitor, that reversal of PARPi-induced EMT and PD-L1 upregulation is blocked.
